Which vitamin deficiency is commonly associated with neuropathy and ataxia?

Vitamin B12 deficiency is commonly associated with neuropathy and ataxia due to its crucial role in the production of myelin, the protective sheath surrounding nerves. When there is a deficiency of this vitamin, it can lead to demyelination, which affects the proper conduction of nerve impulses. This neurological impact can result in symptoms such as peripheral neuropathy, characterized by tingling, numbness, and weakness, as well as ataxia, which manifests as a lack of coordination and balance difficulties.

Vitamin B12 is essential for red blood cell formation, DNA synthesis, and neurological function. Its deficiency can lead to significant neurological deficits, which are particularly pronounced due to its importance in maintaining nerve health. In contrast, the other vitamins listed either do not have such a direct connection to neuropathy or ataxia or are more commonly associated with different clinical manifestations.