Which virus is more commonly associated with Hodgkin's lymphoma?

Prepare for the NBEO Systemic Disease Exam. Use flashcards and multiple-choice questions to test your knowledge. Each question includes hints and explanations. Enhance your understanding and readiness for the exam.

Epstein-Barr Virus (EBV) is the virus most commonly associated with Hodgkin's lymphoma. This association is significant because EBV is known to be involved in the pathogenesis of several lymphoproliferative disorders. In Hodgkin's lymphoma, up to 90% of cases show evidence of EBV infection, particularly in the Reed-Sternberg cells, which are the hallmark of this condition.

The link between EBV and Hodgkin's lymphoma can be attributed to the virus's ability to infect B lymphocytes and induce cellular changes that promote proliferation, survival, and transformation into malignant cells. Additionally, the skewed immune response in individuals infected with EBV may contribute to the development of Hodgkin's lymphoma.

Other viruses listed, such as HIV, can be associated with various lymphomas, including non-Hodgkin lymphoma, but the specific connection with Hodgkin's lymphoma is less pronounced compared to that of EBV. Influenza Virus and Hepatitis B Virus do not have a recognized strong link to the development of Hodgkin's lymphoma in the same way that Epstein-Barr Virus does. Thus, EBV's robust connection to the pathogenesis of this specific cancer makes it the correct answer regarding which virus is more commonly

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