Which tumor types can highly express oncogenes, promoting uncontrolled cellular proliferation?

Carcinomas are malignant tumors that arise from epithelial cells and are known to often express oncogenes. Oncogenes are mutated forms of genes that, when activated, can lead to increased cellular proliferation, survival, and other characteristics associated with cancer. The uncontrolled growth and division of carcinoma cells are a direct result of these oncogenes promoting pathways that override normal regulatory mechanisms in the cell cycle.

While benign tumors do occur, they are generally characterized by localized growth without invasion into surrounding tissues and do not typically show the same high levels of oncogene expression that drive aggressive proliferation seen in carcinomas. Sarcomas, which arise from mesenchymal tissues, can certainly also express oncogenes, but they are a distinct category from carcinomas. Neuroblastomas, a type of cancer that most commonly occurs in adrenal glands or nerve tissue, can also express oncogenes, but they are more specific to the neural crest and are not classified under the broader category of carcinomas.

In summary, carcinomas specifically are known for their high expression of oncogenes, which is a crucial aspect of their aggressive nature and potential for metastasis.