Which phakomatosis is associated with Tuberous sclerosis?

Tuberous sclerosis is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, leading to the development of benign tumors in multiple organs. One of the characteristic findings associated with tuberous sclerosis is the presence of astrocytic hamartomas, which are benign growths found in the brain, particularly in the form of cortical tubers. These hamartomas can lead to seizures and other neurological issues, making them a significant concern in patients with tuberous sclerosis.

Astrocytic hamartomas are specifically linked to the underlying pathology of tuberous sclerosis, as they form due to abnormal growth patterns in neural tissue. Identifying these hamartomas is crucial for diagnosing tuberous sclerosis and managing its systemic effects. This relationship emphasizes the importance of monitoring patients for neurological symptoms and imaging studies to assess for the presence of these lesions.

In contrast, the other options mentioned do not have a direct association with tuberous sclerosis. Neurofibromatosis refers to different genetic conditions entirely, Sturge-Weber syndrome is characterized by facial capillary malformations and associated neurological anomalies, and gestational trophoblastic disease pertains to abnormal growth of trophoblastic cells in the placenta and is unrelated to any phakom