Which of the following is NOT an ocular finding in Osteogenesis Imperfecta?

Prepare for the NBEO Systemic Disease Exam. Use flashcards and multiple-choice questions to test your knowledge. Each question includes hints and explanations. Enhance your understanding and readiness for the exam.

Osteogenesis Imperfecta (OI) is a genetic disorder characterized by brittle bones due to a defect in collagen production. One of the notable ocular manifestations associated with OI is blue sclera, which occurs due to the thinness and translucency of the scleral tissue, allowing the underlying choroidal pigmentation to show through. Keratoconus, a condition where the cornea thins and bulges outward, has also been observed in patients with OI, though it is not as prevalent as other ocular signs. Megalocornea, or enlargement of the cornea, can happen as well but is less frequently documented.

In contrast, scleromalacia perforans is characterized by the thinning and perforation of the sclera due to collagen disorder but is not associated with Osteogenesis Imperfecta. This condition generally arises in patients with systemic diseases that contribute to a more generalized loss of scleral integrity, rather than specifically stemming from the collagen abnormalities seen in OI. Therefore, it is accurate to state that scleromalacia perforans is not an ocular finding associated with Osteogenesis Imperfecta.

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