Which medication is NOT typically associated with causing Aplastic anemia?

Aplastic anemia is a condition characterized by the failure of the bone marrow to produce adequate blood cells, leading to pancytopenia. Several medications are known to potentially cause this serious side effect due to their impact on bone marrow function.

Chloramphenicol is well-documented for its association with aplastic anemia, particularly due to its myelosuppressive effects. Methotrexate, a chemotherapy agent, can also lead to bone marrow suppression, contributing to the risk of aplastic anemia. Acetazolamide, primarily used as a diuretic and for glaucoma, has been reported less frequently in connection with hematological disorders, but it does carry some risk for affecting blood cell production.

On the other hand, tetracycline is a broad-spectrum antibiotic that is not typically associated with bone marrow suppression or aplastic anemia. It works by inhibiting protein synthesis in bacteria and does not have direct effects on blood cell production in the bone marrow. This makes it the least likely candidate among the listed medications to cause aplastic anemia, making it the correct choice.

Understanding the specific pathways and mechanisms through which these medications affect bone marrow can help clarify why certain drugs are implicated in hematological adverse effects while others are not.