Which medication category is frequently associated with causing Peptic Ulcer Disease?

Peptic Ulcer Disease (PUD) is commonly associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are known to cause irritation of the gastric mucosa and impair the protective mechanisms of the stomach lining, leading to an increased risk of ulcer formation. They inhibit the synthesis of prostaglandins, which are substances that maintain the mucosal barrier and promote the secretion of protective mucus in the gastrointestinal tract. When prostaglandin levels are reduced due to NSAID use, the stomach becomes more susceptible to damage from gastric acid, resulting in the development of ulcers.

Other medication categories listed, such as steroids, antidepressants, and antihistamines, may have various side effects, but they are not as strongly linked to the pathogenesis of PUD as NSAIDs. For example, while long-term steroid use can lead to gastrointestinal problems, its contribution to ulcers is not as significant compared to NSAIDs. Antidepressants can have gastrointestinal side effects, but they do not typically lead to ulcer formation. Similarly, antihistamines are used primarily for allergy relief and are not associated with PUD in a direct manner. Thus, NSAIDs remain the most notable category that is linked to the development of peptic ulcers