Which immunoglobulin is predominantly found in the tear film?

Prepare for the NBEO Systemic Disease Exam. Use flashcards and multiple-choice questions to test your knowledge. Each question includes hints and explanations. Enhance your understanding and readiness for the exam.

The predominant immunoglobulin found in the tear film is immunoglobulin A (IgA). This antibody plays a crucial role in the immune defense of mucosal surfaces, including the eyes. In the tear film, IgA helps protect against pathogens by neutralizing viral particles and inhibiting bacterial adhesion, thus contributing to the overall integrity of the ocular surface.

IgA is particularly important because it is secreted into mucosal areas, where it functions in the first line of defense. When considering the different classes of immunoglobulins, IgA is specifically designed for mucosal immunity, which makes it the most relevant in the context of tear film.

Other immunoglobulins present in the immune system, such as IgE, IgG, and IgM, serve different functions. IgE is associated with allergic reactions and responses to parasitic infections. IgG is the most abundant immunoglobulin in the bloodstream and plays a vital role in systemic immune responses. IgM is the first antibody produced in response to an infection but is not primarily involved in mucosal immunity. Therefore, the unique role of IgA in mucosal surfaces and its predominant presence in tear film make it the correct answer.

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