Which condition is characterized by hypercortisolism and presents with central obesity and moon face?

Prepare for the NBEO Systemic Disease Exam. Use flashcards and multiple-choice questions to test your knowledge. Each question includes hints and explanations. Enhance your understanding and readiness for the exam.

Cushing's Syndrome is characterized by hypercortisolism, which leads to a variety of clinical features, including central obesity and a distinctive facial appearance known as "moon face." In this condition, the excess cortisol can result from various causes, including pituitary adenomas, adrenal tumors, or ectopic production of ACTH.

The central obesity observed in Cushing's Syndrome refers to the accumulation of fat in the abdomen, while the moon face is attributed to fat deposition in the facial area and can give the face a rounded appearance. Other manifestations of hypercortisolism may include skin changes, hypertension, glucose intolerance, and muscle weakness, making it a complex endocrine disorder.

Addison's Disease, in contrast, is characterized by adrenal insufficiency and does not present with hypercortisolism; rather, it often leads to weight loss, fatigue, and skin hyperpigmentation. Pheochromocytoma primarily involves catecholamine excess and is characterized by symptoms like hypertension and palpitations rather than hypercortisolism. Hyperaldosteronism involves excessive aldosterone secretion, leading to hypertension and hypokalemia without the typical signs of hypercortisolism seen in Cushing's Syndrome. These distinctions highlight the specific

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