Which autosomal recessive systemic condition is associated with sea fan proliferative retinopathy?

The condition associated with sea fan proliferative retinopathy is indeed linked to sickle cell anemia, which is an autosomal recessive disorder. In sickle cell anemia, the abnormal hemoglobin leads to sickling of red blood cells, which can obstruct small blood vessels and cause ischemia in various tissues, including the retina. The resulting retinal changes can manifest as sea fan proliferative retinopathy, characterized by the formation of new blood vessels and fibrous tissue resembling a sea fan.

While the other conditions mentioned have their own systemic implications, they do not relate to the specific retinal findings observed in sickle cell anemia. For example, Marfan's syndrome is primarily associated with connective tissue abnormalities and does not present the same retinal complication. Huntington's chorea is a neurodegenerative disorder with genetic implications but is not associated with retinal vascular issues. Similarly, familial adenomatous polyposis involves the gastrointestinal system, specifically a predisposition to colorectal cancer, and does not produce the eye findings linked to sickle cell disease. Thus, sickle cell anemia is correctly identified as the systemic condition associated with sea fan proliferative retinopathy.