Which autosomal dominant condition is most associated with pursuits affecting EOMs?

Huntington's Chorea is primarily characterized by progressive motor dysfunction, including chorea, which can significantly affect various muscle groups, including those responsible for eye movements. In this condition, the involvement of the extraocular muscles (EOMs) can manifest as difficulties with eye tracking and coordination due to the degeneration of specific neuronal pathways in the basal ganglia and cortex that control voluntary movements. This correlation positions Huntington's Chorea as the autosomal dominant condition most associated with pursuits affecting eye movements.

In contrast, the other conditions listed do have systemic effects or ocular manifestations, but they do not predominantly affect the extraocular muscles in the same way. For example, Von Hippel Lindau primarily causes retinal issues related to hemangioblastomas rather than direct involvement of eye movement control. Marfan's Syndrome is more associated with systemic connective tissue issues and ocular complications like lens dislocation, which do not explicitly impair the motor control of EOMs. Neurofibromatosis Type 1 primarily presents with neurofibromas and other systemic complications but is not directly linked with the specific dysfunction of eye movements.