What type of necrosis results from ischemia or infarction affecting solid organs?

Coagulative necrosis is the type of tissue death that occurs as a result of ischemia or infarction, particularly in solid organs such as the heart, kidneys, and spleen. This process is characterized by the preservation of the basic tissue architecture, even though the cells have died. The affected tissue becomes firm and waxy, and the cellular components become denatured due to the loss of blood supply, leading to the disruption of cellular metabolism and subsequent cell death.

In coagulative necrosis, the most common cause is the cessation of blood flow, which leads to the deprivation of oxygen and nutrients to the tissues. This type of necrosis is often seen in conditions like myocardial infarction and renal tubular necrosis, where blood flow is abruptly interrupted.

This is distinct from liquefactive necrosis, which typically occurs in the brain and in bacterial infections, resulting in the liquefying of tissues. Caseous necrosis, commonly associated with tuberculosis, leads to the formation of cheese-like (caseous) necrotic tissue. Fat necrosis generally occurs in pancreatic damage or trauma to adipose tissue and involves the enzymatic destruction of fat tissue. Each of these types has characteristic features and causes, but coagulative necrosis is specifically linked