What is the predominant cell type found in Acute Leukemia?

Prepare for the NBEO Systemic Disease Exam. Use flashcards and multiple-choice questions to test your knowledge. Each question includes hints and explanations. Enhance your understanding and readiness for the exam.

In acute leukemia, the predominant cell type is indeed blast cells. This corresponds to the underlying pathology of acute leukemia, which is characterized by the rapid proliferation of immature blood cells that are not fully developed and functional. These blast cells typically have a high nucleus-to-cytoplasm ratio, prominent nucleoli, and scant cytoplasm, indicating that they are early precursors in the differentiation of hematopoietic cells.

The presence of these blast cells is critical for both diagnosis and classification of acute leukemia, as they can be further classified into different subtypes based on their lineage—whether myeloid or lymphoid. In acute myeloid leukemia (AML), the blasts are myeloid in origin, while in acute lymphoblastic leukemia (ALL), they are lymphoid. Regardless of the subtype, the abundance of blast cells is a defining feature of this disease.

In contrast, the other cell types mentioned, like myeloid cells, B cells, and T cells, serve different roles in the context of hematopoiesis and the immune system but are not the predominant cell type observed in acute leukemia. Myeloid cells refer to a more mature stage of granulocyte or monocyte lineage, while B and T cells represent specific mature lymphocyte

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