What autoimmune disease is characterized by autoantibodies directed against acetylcholine receptors in the neuromuscular junction?

Myasthenia Gravis is an autoimmune disease in which the immune system produces autoantibodies that target acetylcholine receptors at the neuromuscular junction. This leads to impaired communication between nerves and muscles, resulting in muscle weakness and fatigue that worsens with activity and improves with rest. The hallmark feature of the disease is the presence of these specific autoantibodies, which are critical for diagnosis.

In contrast, Duchenne Muscular Dystrophy is a genetic disorder caused by mutations affecting the dystrophin protein, leading to progressive muscle degeneration. It is not an autoimmune condition and does not involve autoantibodies targeting receptors.

Guillain-Barre Syndrome is an acute inflammatory demyelinating polyneuropathy often triggered by infections. While it involves an autoimmune response, it specifically targets the peripheral nervous system rather than the neuromuscular junction.

Multiple Sclerosis is another autoimmune condition, but it primarily affects the central nervous system by targeting myelin rather than the neuromuscular junction or acetylcholine receptors.

Understanding the specific mechanism and target of Myasthenia Gravis highlights why it is the correct answer in this context.