What are the two main locations where Peptic Ulcer Disease can occur?

Peptic Ulcer Disease primarily involves ulcers forming in specific areas of the gastrointestinal tract that are exposed to gastric acid and pepsin. The two main types of ulcers associated with this condition are gastric ulcers and duodenal ulcers.

Gastric ulcers occur in the stomach lining, where excess acid secretion or other irritants can lead to the breakdown of the mucosal barrier. This results in inflammation and ulceration of the stomach wall.

Duodenal ulcers, on the other hand, are found in the first part of the small intestine (the duodenum). These ulcers typically arise due to similar causes, such as the presence of Helicobacter pylori infection, excessive NSAID use, or chronic stress, leading to an imbalance between protective factors and aggressive factors like acid secretion.

The other options, while mentioning regions of the digestive tract, do not accurately represent the primary locations for peptic ulcers. The jejunum and ileum, which are parts of the small intestine further along from the duodenum, are not typical sites for peptic ulcers associated with this condition. Therefore, identifying gastric and duodenal as the main sites provides a clear understanding of where peptic ulcer disease predominantly manifests.