Juvenile Idiopathic Arthritis will often have a ____________ RF and ____________ ANA.

Juvenile Idiopathic Arthritis (JIA) is characterized by its abnormal immune responses that typically do not show the same serological features as adult forms of rheumatoid arthritis. In most cases of JIA, the rheumatoid factor (RF) is negative, meaning that patients usually do not produce the RF antibody, which distinguishes it from many adult rheumatologic conditions where RF may be positive.

Additionally, the antinuclear antibody (ANA) can frequently be positive in juvenile idiopathic arthritis, particularly in the oligoarticular form, where there is a higher prevalence of ANA positivity. This antibody is often associated with an increased risk of uveitis, an important consideration in the management of these patients.

Thus, the correct response highlights the association of juvenile idiopathic arthritis with a negative rheumatoid factor and a positive antinuclear antibody, accurately reflecting the common serological findings in this population. This knowledge is crucial for diagnosing and managing JIA and ensuring appropriate monitoring for complications like uveitis.