In which of the following conditions is whorl keratopathy commonly found?

Whorl keratopathy, also known as vortex keratopathy, is characteristically observed in Fabry's disease, an X-linked lysosomal storage disorder caused by the deficiency of the enzyme alpha-galactosidase A. This deficiency leads to the accumulation of globotriaosylceramide (GL-3) in various tissues, including the cornea. The deposition of these substances in the corneal epithelium results in the distinctive whorl-like patterns seen in patients with Fabry's disease.

The appearance of whorl keratopathy often serves as a crucial clinical clue in identifying individuals who may have this genetic condition, especially if they also present with other systemic manifestations such as pain, skin lesions, and cardiovascular complications. Thus, when evaluating a patient with potential systemic diseases, the presence of whorl keratopathy may prompt further investigation into Fabry's disease as a possible underlying condition.

In comparison, the other conditions listed are not typically associated with whorl keratopathy. Osteogenesis imperfecta primarily affects collagen formation and has different ocular manifestations, while diabetic retinopathy and Stargardt disease are primarily related to retinal pathologies without a direct association to keratopathy patterns. Therefore, the presence of whorl ker